Cardurion Pharmaceuticals Announces Investment of up to $300 Million from Bain Capital

Investment to support Cardurion’s further evolution into a cardiovascular leader

BOSTON – October 27, 2021 – Cardurion Pharmaceuticals, Inc. (“Cardurion” or “the Company”), a clinical-stage biotechnology company focused on the discovery and development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases, today announced it has received a private investment of up to $300 million from Bain Capital Life Sciences and Bain Capital Private Equity. Bain Capital joins existing investors, Takeda Pharmaceuticals and Polaris Partners, in supporting the evolution of Cardurion into a leading cardiovascular biotechnology company. Based in Boston, Massachusetts and with facilities there and in Shonan, Japan, Cardurion’s mission is to transform the treatment of cardiovascular diseases by translating the science of cardiovascular signaling pathways into groundbreaking therapeutics. The Company’s innovative pipeline of cardiovascular drug candidates includes a PDE9 inhibitor and a CaMKII inhibitor program. The investment will support the thoughtful advancement of Cardurion’s pipeline, enable the Company to scale its team, and create an industry-leading platform. “We could not be more excited to welcome Bain Capital as investors in this transformational milestone for Cardurion,” said Peter Lawrence, Chief Executive Officer of Cardurion. “We have a shared vision to continue to build a world-class cardiovascular company pursuing treatments for a broad range of debilitating diseases. This funding will allow us to advance our first-in-class PDE9 inhibitor into a major Phase 2 trial in heart failure and to support the initiation of first-in-human studies with our CaMKII inhibitor program in several cardiovascular indications. We look forward to leveraging the experience and resources of our investors to build and scale Cardurion as a leading cardiovascular biotechnology company.” “This is an impressive team laser-focused on deep science, innovation, and collaboration in a strategically important therapeutic area where there is high unmet need for patients,” said Adam Koppel, M.D., PhD, a Managing Director at Bain Capital Life Sciences. “We look forward to a lasting partnership with Mike and Peter and their team, supporting the efforts to identify and develop novel therapies while building out a scale platform that can serve as a champion for cardiovascular drug development.” “This investment will accelerate our progress as we work to create transformative new medicines that deliver value for patients and other key stakeholders,” said Michael E. Mendelsohn, M.D., Founder and Chairman of Cardurion. “Cardurion is dedicated to advancing novel mechanisms that yield new treatments for cardiovascular disease, which remains the greatest cause of morbidity and mortality in our society.” In conjunction with Bain Capital’s investment, Koppel and Nicholas Downing, MD, a Principal at Bain Capital Life Sciences, will join the Cardurion Board of Directors.

###

About Cardurion Pharmaceuticals Cardurion Pharmaceuticals is a clinical-stage biotechnology company focused on the discovery and development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Founded by physician-scientist Michael E. Mendelsohn, M.D., and built by a team of physician-scientists and industry leaders with extensive experience in cardiovascular science, drug development and business development, Cardurion Pharmaceuticals is pursuing unique drug discovery and development programs to target major unmet needs in cardiovascular medicine. Cardurion Pharmaceuticals has facilities in Boston, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com. About Bain Capital Founded in 1984, Bain Capital, LP is one of the world’s leading private multi-asset alternative investment firms with offices on four continents and deep experience in healthcare. Bain Capital manages approximately $150 billion across asset classes and leverages the firm’s shared platform to capture opportunities in strategic areas of focus. Bain Capital Private Equity has partnered closely with management teams to provide the strategic resources that build great companies and help them thrive. A team of more than 275 investment professionals creates value for portfolio companies through its global platform and depth of expertise in key vertical industries including healthcare. Bain Capital Life Sciences pursues investments in biopharmaceutical, specialty pharmaceutical, medical device, diagnostics and enabling life science technology companies globally. The team focuses on companies that both drive medical innovation across the value chain and enable that innovation to improve the lives of patients with unmet medical needs.   Media Contact: Scott Lessne Stanton slessne@stantonprm.com 646-502-3569

Read More

Cardurion Pharmaceuticals Announces Appointment of Howard K. Surks, M.D., as Chief Scientific Officer and Head, Translational Medicine

Appointment reflects progress of Company’s early-stage pipeline toward the clinic

BOSTON, Mass., December 14, 2020 – Cardurion Pharmaceuticals, Inc. (Cardurion), a Boston-based, clinical-stage biotechnology company focused on discovering and developing next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases, today announced the appointment of Howard K. Surks, M.D., as chief scientific officer and head, translational medicine. Dr. Surks joins Cardurion from Sanofi where he most recently served as head, translational medicine and clinical pharmacology U.S.

“We are very gratified that Howard has decided to join the Cardurion team at a time when our early-stage pipeline is moving rapidly toward the clinic,” said Peter Lawrence, chief executive officer of Cardurion. “Howard’s decades-long leadership encompassing cardiovascular drug discovery and development at Sanofi and Merck, and his basic cardiovascular research experience at Tufts Medical Center and School of Medicine, add to our already strong scientific team and ensure that we will have the expertise and experience needed to guide our early-stage programs into innovative human clinical trials.”

As head of translational medicine and clinical pharmacology U.S. at Sanofi, Dr. Surks recruited and led a team focused on research and early clinical development of molecules across multiple therapeutic areas. Prior to Sanofi, Dr. Surks worked in both translational medicine and cardiovascular clinical development at Merck. Dr. Surks has led or overseen translational medicine and clinical pharmacology in multiple preclinical and clinical programs for cardiovascular diseases, rare diseases, hematology and immunology. Before joining the pharmaceutical industry, Dr. Surks was an associate professor of medicine at the Molecular Cardiology Research Institute of Tufts Medical Center and School of Medicine, where he led an NIH-funded laboratory focused on cardiovascular signal transduction pathways and served on the cardiology division clinical faculty. Dr. Surks trained in cardiology and internal medicine at Tufts Medical Center.

“Cardurion is emerging as a leader in cardiovascular drug discovery and development, and I am excited to join the company to help move its novel portfolio of preclinical drug candidates into clinical trials,” said Dr. Surks. “Cardurion has the opportunity to change and improve the treatment paradigm in heart failure and other cardiovascular diseases, and I am thrilled to partner with such an experienced leadership team to bring transformative new medicines to patients in areas of great unmet need.”

 

About Cardurion Pharmaceuticals

Cardurion Pharmaceuticals is a clinical-stage biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Built by a team of physician-scientists and industry experts with extensive experience in cardiovascular science, medicine and drug development, Cardurion Pharmaceuticals is pursuing unique drug discovery and development programs to target major unmet needs in cardiology. Cardurion Pharmaceuticals has facilities in Boston, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

 

Media Contact

Gwen Schanker
Ten Bridge Communications
gwen@tenbridgecommunications.com
269-921-3607

Read More

Cardurion Pharmaceuticals Announces Appointment of Chris Morabito, M.D., as Chief Medical Officer

 Appointment reflects growing strength and diversity of Cardurion’s pipeline

July 08, 2020 08:00 AM Eastern Daylight Time

BOSTON–(BUSINESS WIRE)–Cardurion Pharmaceuticals, Inc. (Cardurion), a Boston-based, clinical-stage biotechnology company focused on discovering and developing next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases, today announced the appointment of Chris Morabito, M.D., as chief medical officer (CMO). Dr. Morabito joins Cardurion from Takeda Pharmaceuticals, where he most recently served as senior vice president and head, research and development (R&D), plasma-derived therapies, and where he previously served as vice president and global program leader, specialty cardiovascular (CV) disease.

“Cardurion has the opportunity to deliver life-changing therapies against previously un-drugged targets in heart failure and other cardiovascular diseases. I am delighted to be partnering with our experienced leadership team and look forward to helping the company bring transformative new medicines to patients.”

“We are thrilled that Chris is bringing to Cardurion his strong industry and operational leadership at a time when our lead program in heart failure is advancing in the clinic and our pipeline is maturing,” said Peter Lawrence, chief executive officer of Cardurion. “Chris has a deep background in cardiovascular drug development from his time at Takeda, Sanofi and Merck, as well as broad experience and skills in leading large groups and an array of mission critical projects. His vision and leadership will be essential to our ongoing work to bring transformative therapies to people with cardiovascular diseases.”

As head, R&D, plasma-derived therapies at Takeda, Dr. Morabito established a complete R&D organization and built a pipeline of life-transforming medicines for patients with rare and difficult-to-manage diseases. Prior to that, he served as head, pipeline strategy for global R&D at Takeda, where he influenced the integrated development of R&D programs across Takeda’s therapeutic areas. While in this role, Dr. Morabito was instrumental in the acquisition and integration of Shire that occurred in 2019. Dr. Morabito has extensive experience in cardiovascular disease drug development. He has led numerous programs in heart failure, pulmonary hypertension, atrial fibrillation, hypertension and diabetes mellitus at Merck, Sanofi and Takeda. He has overseen numerous Phase 1, proof-of-concept and pivotal studies, including CV outcome studies. Dr. Morabito trained initially as a neonatologist at the Cardiovascular Research Institute at University of California, San Francisco, where he focused on neonatal cardiology and was an NIH-funded scientist interrogating mechanisms of cardiomyocyte development.

“I am excited to join Cardurion at this important time, when both our lead program and broader pipeline are entering important phases in the development cycle,” said Dr. Morabito. “Cardurion has the opportunity to deliver life-changing therapies against previously un-drugged targets in heart failure and other cardiovascular diseases. I am delighted to be partnering with our experienced leadership team and look forward to helping the company bring transformative new medicines to patients.”

About Cardurion Pharmaceuticals

Cardurion Pharmaceuticals is a clinical-stage biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Built by a team of physician-scientists and industry experts with extensive experience in cardiovascular science, medicine and drug development, Cardurion Pharmaceuticals is pursuing unique drug discovery and development programs to target major unmet needs in cardiology. Cardurion Pharmaceuticals has facilities in Boston, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com

 

Contacts
Gwen Schanker
Ten Bridge Communications
gwen@tenbridgecommunications.com
269-921-3607

Read More

Cardurion Pharmaceuticals Announces Appointment of Peter Lawrence as President and Chief Executive Officer

April 15, 2020 07:30 AM Eastern Daylight Time

BOSTON – (BUSINESS WIRE Cardurion Pharmaceuticals, Inc. (Cardurion), a Boston-based, clinical-stage biotechnology company focused on discovering and developing next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases, today announced the appointment of Peter S. Lawrence as president and chief executive officer. Mr. Lawrence joins Cardurion after serving for almost 14 years as president and chief operating officer of ArQule, Inc., which was successfully sold to Merck in January 2020 for $2.7 billion. Mr. Lawrence succeeds Michael E. Mendelsohn, M.D., founder and interim CEO of Cardurion, who will continue in his role as chairman of Cardurion’s Board of Directors.

“Pete’s demonstrated success as a skilled and experienced biotechnology leader will be a tremendous asset to Cardurion as we progress our preclinical and clinical-stage pipeline of cardiovascular drug candidates into later-stage clinical development and ultimately to market,” said Dr. Mendelsohn. “His leadership will be critical to guiding Cardurion as we realize our long-term vision to bring life-changing new therapies to patients with heart disease.”

Mr. Lawrence brings more than 20 years of experience as a life sciences executive and investor with a track record of company building, deal making and operational leadership. In addition to his strategic role as president of ArQule, Mr. Lawrence oversaw the company’s R&D and manufacturing operations as well as its corporate and business development, new product planning, IT, legal and IP functions. Concurrently, he served as principal financial officer for ArQule and in that role helped raise over $350 million through six public financings. Additionally, Mr. Lawrence facilitated collaborations with ArQule’s pharmaceutical and biotechnology partners, overseeing partnerships with a total value in excess of $1 billion and providing the company hundreds of millions of dollars in milestone payments and development support. Before joining ArQule, Mr. Lawrence was a founder and general partner of Pod Venture Partners and previously was a corporate law equity partner at Mintz Levin. He holds a degree in history and Russian studies from Amherst College and a J.D. from Boston University School of Law.

“The Cardurion team is applying its deep cardiovascular expertise, strong drug discovery and clinical development backgrounds and an extensive industry and academic network to acquire and discover novel drug candidates to address cardiovascular disease,” said Mr. Lawrence. “I am excited about the opportunity to lead this talented team as we progress our most advanced clinical program into later-stage clinical testing in both forms of heart failure, while also bringing forward our preclinical pipeline of novel cardiovascular medicines.”

About Cardurion Pharmaceuticals

Cardurion Pharmaceuticals is a clinical-stage biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Built by a team of physician-scientists and industry experts with extensive experience in cardiovascular science, medicine and drug development, Cardurion Pharmaceuticals is pursuing unique drug discovery and development programs to target major unmet needs in cardiology. Cardurion Pharmaceuticals has facilities in Boston, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

 

Media Contact
Gwen Schanker
Ten Bridge Communications
gwen@tenbridgecommunications.com
269-921-3607

Read More

Cardurion Pharmaceuticals Announces Investment from Polaris Partners and Appoints Amy Schulman to Board of Directors

BOSTON, Mass. – November 20, 2019 – Cardurion Pharmaceuticals, a biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases, today announced that it has consummated a private investment from Polaris Partners, a leading healthcare investment firm with a long history of partnering with entrepreneurs in biotechnology. Polaris Partners joins existing investor Takeda Pharmaceuticals. As part of the investment, Amy W. Schulman, a managing partner at Polaris Partners, will join the Cardurion Board of Directors.

“We are honored to have Polaris Partners, with its long history of leadership in biotechnology investing and company building, partner with us as we pursue novel drugs to treat cardiovascular diseases, and we are especially pleased to have Amy Schulman of Polaris bring her deep strategic and leadership experience to our board,” said Dr. Michael E. Mendelsohn, founder and chairman of Cardurion Pharmaceuticals. “Cardurion is dedicated to advancing novel mechanisms to create new treatments for cardiovascular diseases, which remain the greatest cause of morbidity and mortality in our society. Our lead clinical program studying CRD-733, a novel phosphodiesterase-9 enzyme (PDE9) inhibitor, is in development for the treatment of heart failure, which remains a major cause of death in our society. Our two discovery programs focus on unique molecular targets for other cardiovascular diseases, including both rare and more common arrhythmia disorders.”

Amy W. Schulman, a managing partner at Polaris Partners who will be joining Cardurion’s board, noted that cardiovascular disease affects millions of people in the United States alone. “This area of clear critical need, coupled with Michael’s deep expertise in the field, were important factors in Polaris’ decision to invest. Cardurion’s robust pipeline programs, led by a PDE9 inhibitor already in the clinic for the treatment of both forms of heart failure, are also factors underscoring Polaris’ enthusiasm for this platform.”

The securities issued have not been registered under the Securities Act of 1933 and may not be offered or sold in the United States absent registration or an applicable exemption from registration under the Securities Act and applicable state securities laws. This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state in which such offer, solicitation or sale would be unlawful.

 

About Cardurion Pharmaceuticals

Cardurion Pharmaceuticals is a biotechnology company with both clinical and preclinical programs focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Founded by physician-scientist Michael E. Mendelsohn, M.D., with extensive experience in cardiovascular science, medicine and drug development, Cardurion Pharmaceuticals is pursuing unique drug discovery and development programs targeting major unmet needs in cardiovascular medicine. Cardurion Pharmaceuticals has facilities in Boston, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

 

About Polaris Partners

Polaris Partners has a 20-plus year history of partnering with repeat entrepreneurs and world-class innovators who are improving the way we live and work. The multibillion-dollar firm manages specialty and diversified funds in healthcare and technology with investments across all stages. Polaris has offices in Boston and San Francisco. Learn more at polarispartners.com.

Investor and Media Contact

Michael E. Mendelsohn, M.D.

Cardurion Pharmaceuticals

info@cardurion.com

617-863-8088

Read More

Cardurion Pharmaceuticals Presents Preclinical Data for CRD-733 at the American Heart Association Scientific Sessions and Announces Initiation of Phase 1b Study in Patients with Heart Failure
CRD-733 treatment reduced or reversed several markers of heart failure and reversed pressure overload-induced cardiac hypertrophy in animal models

November 12, 2018 09:00 AM Eastern Standard Time

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Cardurion Pharmaceuticals, a biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of cardiovascular diseases, today announced preclinical results from its study of CRD-733, the company’s novel Phosphodiesterase-9 enzyme (PDE-9) inhibitor, in a poster presentation at the American Heart Association (AHA) Scientific Sessions in Chicago. In a study of mice with left ventricular hypertrophy (LVH) in a standard preclinical heart failure model, mice treated with CRD-733 were protected from LVH and showed improvement in several other markers of heart failure.

“These data provide strong evidence for the potential therapeutic benefit of PDE9 inhibition in a preclinical model of heart failure,” said Daniel Bloomfield, M.D., chief executive officer at Cardurion Pharmaceuticals. “Based on these data, and the established safety and tolerability of CRD-733 in humans, we are excited to announce initiation of the first clinical trial of CRD-733 in patients with heart failure.”

As a result of Cardurion Pharmaceuticals’ preclinical data, the recent successful Phase 1 study in normal subjects, and the safety and tolerability of CRD-733 in more than 250 subjects to date, the company has now initiated its Phase 1b study in heart failure. The randomized, double-blind study is evaluating CRD-733 in patients with heart failure in the U.S. and Europe. The trial will include 44 patients in each sub-population of heart failure, heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). Results are expected in 2019.

About CRD-733
CRD-733 is a Phosphodiesterase-9 enzyme (PDE-9) inhibitor. PDE-9 activity is abnormally elevated in heart failure which can impede activation of the heart’s normal responses to stress and make the heart more vulnerable to damage. In preclinical models of heart failure, inhibiting PDE-9 with CRD-733 restores these heart-protective mechanisms and has been shown to prevent and reverse heart muscle malfunction brought on by abnormal stress. Cardurion Pharmaceuticals obtained an exclusive, worldwide, royalty-bearing license from Astellas to research, develop, manufacture and commercialize CRD-733 for the diagnosis, prevention, and treatment of cardiovascular-related indications in humans.

About Heart Failure
Heart failure is marked by progressive weakening or stiffening of the heart muscle and the organ’s gradual loss of blood-pumping ability. Although symptoms can be managed, this is a chronic condition with no cure. With more than 26 million people with heart failure worldwide1 and 6.5 million people with heart failure in the United States2, heart failure is the most important remaining unmet need in cardiovascular disease. In the United States, heart failure accounts for more than 1 million hospital admissions2 and costs approximately $30 billion dollars each year to treat3. Not only are these costs expected to rise to almost $70 billion by 20303, the incidence of heart failure is projected to rise 46 percent – resulting in more than 8 million people with heart failure in the United States4. There are two forms of heart failure: heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). HFrEF, formerly known as systolic heart failure, is characterized by a decrease in the ability of the heart to eject blood sufficiently during contraction. HFpEF is the form of heart failure that occurs when the left ventricle becomes stiff and though it continues to eject blood normally, in HFpEF the heart’s ability to relax is reduced, causing it to be unable to fill with blood sufficiently. The prognosis of patients with HFpEF is similar to that of HFrEF5. Roughly half of the patients with heart failure have HFpEF5, for which there are no approved therapies.

About Cardurion Pharmaceuticals
Cardurion Pharmaceuticals is a biotechnology company with both clinical and preclinical programs focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Led by two physician-scientists with extensive experience in cardiovascular science, medicine, and drug development, Cardurion Pharmaceuticals’ unique programs and strongly collaborative environment enable the company to deliver promising treatments that target major unmet needs. Cardurion Pharmaceuticals has facilities in Cambridge, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

Cardurion Pharmaceuticals’ Forward-Looking Statements
This press release contains forward-looking statements, all of which are qualified in their entirety by this cautionary statement. Any statements contained herein that do not describe historical facts, are forward-looking statements that are based on management’s expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcomes, timing and performance to differ materially from those expressed or implied by such statements. These factors, risks and uncertainties include, but are not limited to: the costs and uncertainties associated with our research efforts and other discovery activities; the inherent uncertainties associated with the conduct, timing and results of preclinical and clinical studies of our product candidates; and the adequacy of our capital resources and availability of additional funding. Except as otherwise noted, these forward-looking statements speak only as of the date of this press release, and we undertake no obligation to update or revise any of such statements to reflect events or circumstances occurring after this press release. We caution readers not to place undue reliance on the forward-looking statements contained in this press release.

The safety and efficacy of the agent discussed herein are under investigation and have not been established. There is no guarantee that the agent will receive regulatory approval and become commercially available for the uses being investigated. Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice.

Global Public Health Burden of Heart Failure. Cardiac Failure Review (2017)
American Heart Association, Causes and Risks for Heart Failure (February 2018)
Circ Heart Fail. 2013 May ; 6(3): 606–619. doi:10.1161/HHF.0b013e318291329a
American Heart Association, Heart Disease and Stroke Statistics (January 2017)
5 Owen et al (2006) N Engl J Med

Contacts

W2O pure
Anne Lucke, +1 646-698-8474
alucke@w2ogroup.com

Read More

Silvia Priori, M.D., Ph.D. Delivers the William Harvey Lecture on Basic Science

CAMBRIDGE, MASS. – [October 2, 2018] – The European Society of Cardiology Congress holds four specialized lectures each year and selects four renowned scientists who are seen by their peers as leading experts in their corresponding fields. The William Harvey Lecture on Basic Science is a noteworthy accolade and recognizes a member of the scientific community specializing in cardiology.

Silvia Priori, M.D., Ph.D. was selected to deliver the William Harvey Lecture on Basic Science this year. On August 26th, Dr. Priori spoke about her inherited arrhythmogenic diseases study and the significant developments it has made in understanding the genetic basis of these types of diseases. With these results, she hopes to provide a foundation for gene therapies to fix the consequences of the flawed genes and bring new treatments to the clinic.

“Receiving the Harvey Lecture Award is really a great feeling and arrived at a time in which the advancements in molecular medicine are reaching the clinics with the promise of a better future for our patients,” said Dr. Priori.

Dr. Priori is a professor of Cardiology in the Department of Molecular Medicine at the University of Pavia, scientific director and director of the Cardiology Division at the Istituti Clinici Scientifici Maugeri and a director of the Molecular Cardiology Laboratories at the Centro National de Investigaciones Cardiovasculares Carlos III. Dr. Priori has received numerous prestigious honors and awards from scientific societies around the world, including the Distinguished Scientist Award of the Heart Rhythm Society and the Outstanding Research in Pediatric Cardiology award of the American Heart Association. Dr. Priori joined the Cardurion Pharmaceuticals scientific advisory board in September 2018.

Read More

Cardurion Pharmaceuticals Announces Initiation of Phase 1 Study of CRD-733, a PDE-9 Inhibitor in Development for the Treatment of Heart Failure

CAMBRIDGE, MASS. – [September 20, 2018] – Cardurion Pharmaceuticals, a biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of cardiovascular diseases, today announced that the U.S. Food and Drug Administration (FDA) has accepted its Investigational New Drug Application (IND) for CRD-733, a Phosphodiesterase-9 (PDE-9) inhibitor in development to improve cardiac function in heart failure patients. Recent evidence supports that inhibition of PDE-9 has the potential to restore heart-protective mechanisms that are dysfunctional in heart failure, as well as improve heart muscle function and size. A Phase 1 clinical trial to evaluate the safety, pharmacokinetics and pharmacodynamics of orally administered single and multiple doses of CRD-733 in healthy volunteers was recently initiated.

“The advancement of CRD-733 into the clinic is an important milestone for Cardurion as we move our portfolio’s lead program forward toward treatment of heart failure, the most important unmet need in cardiovascular medicine,” said Daniel Bloomfield, M.D., chief executive officer at Cardurion Pharmaceuticals. “Compelling preclinical evidence supports that CRD-733 can enhance cardiac function in both known forms of heart failure. With limited options at present for those living with heart failure, we are excited about the potential for CRD-733 to have a positive impact on these patients.”

Cardurion Pharmaceuticals entered an exclusive licensing agreement with Astellas to develop and commercialize CRD-733 earlier this year.

About CRD-733

CRD-733 is a Phosphodiesterase-9 enzyme (PDE-9) inhibitor. PDE-9 activity is abnormally elevated in heart failure which can impede activation of the heart’s normal responses to stress and make the heart more vulnerable to damage. In preclinical models of heart failure, inhibiting PDE-9 with CRD-733 restores these heart-protective mechanisms and has been shown to prevent and reverse heart muscle malfunction brought on by abnormal stress. Cardurion Pharmaceuticals obtained an exclusive, worldwide, royalty-bearing license from Astellas to research, develop, manufacture and commercialize CRD-733 for the diagnosis, prevention, and treatment of cardiovascular-related indications in humans.

About Heart Failure

Heart failure is marked by progressive weakening or stiffening of the heart muscle and the organ’s gradual loss of blood-pumping ability. Although symptoms can be managed, this is a chronic condition with no cure. With more than 26 million people with heart failure worldwide1 and 6.5 million people with heart failure in the United States,2 heart failure is the most important remaining unmet need in cardiovascular disease. In the United States, heart failure accounts for more than 1 million hospital admissions2 and costs approximately $30 billion dollars each year to treat3. Not only are these costs expected to rise to almost $70 billion by 20303, the incidence of heart failure is projected to rise 46 percent – resulting in more than 8 million people with heart failure in the United States4.

About Cardurion Pharmaceuticals

Cardurion Pharmaceuticals is a biotechnology company with both clinical and preclinical programs focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Led by two physician-scientists with extensive experience in cardiovascular science, medicine, and drug development, Cardurion Pharmaceuticals’ unique programs and strongly collaborative environment enable the company to deliver promising treatments that target major unmet needs. Cardurion Pharmaceuticals has facilities in Cambridge, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

Cardurion Pharmaceuticals’ Forward Looking Statements

This press release contains forward-looking statements, all of which are qualified in their entirety by this cautionary statement. Any statements contained herein that do not describe historical facts, are forward-looking statements that are based on management’s expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcomes, timing and performance to differ materially from those expressed or implied by such statements. These factors, risks and uncertainties include, but are not limited to: the costs and uncertainties associated with our research efforts and other discovery activities; the inherent uncertainties associated with the conduct, timing and results of preclinical and clinical studies of our product candidates; and the adequacy of our capital resources and availability of additional funding. Except as otherwise noted, these forward-looking statements speak only as of the date of this press release, and we undertake no obligation to update or revise any of such statements to reflect events or circumstances occurring after this press release. We caution readers not to place undue reliance on the forward-looking statements contained in this press release.

The safety and efficacy of the agent discussed herein are under investigation and have not been established. There is no guarantee that the agent will receive regulatory approval and become commercially available for the uses being investigated. Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice.

Global Public Health Burden of Heart Failure. Cardiac Failure Review (2017)

American Heart Association, Causes and Risks for Heart Failure (February 2018)

Circ Heart Fail. 2013 May ; 6(3): 606–619. doi:10.1161/HHF.0b013e318291329a

American Heart Association, Heart Disease and Stroke Statistics (January 2017)

Media
Stephanie Hutton
W2O pure
shutton@w2ogroup.com
+1 910.726.1367

Read More

Cardurion Pharmaceuticals Appoints Jeb Keiper to Its Board of Directors

CAMBRIDGE, MASS. – [August 16, 2018] – Cardurion Pharmaceuticals, a biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of cardiovascular diseases, today announced the appointment of industry leader, Jeb Keiper, as an independent member of its Board of Directors. Mr. Keiper joins founder Michael Mendelsohn, M.D., Ken Novack, Ed Mascioli, M.D. and chief executive officer Daniel Bloomfield, M.D. as members, along with board observers, Stephen Hitchcock, Ph.D. and Keith Gottesdiener, M.D.

“We are fortunate to have amassed a tremendous breadth and depth of expertise in drug discovery, development, and business amongst our board members, observers and advisors, which positions Cardurion well to deliver on our vision of becoming the world’s leading cardiovascular drug company,” said Daniel Bloomfield, M.D., chief executive officer at Cardurion Pharmaceuticals. “We are thrilled to have Jeb share his expertise and leadership skills as Cardurion takes on the challenges and opportunities of the company’s next critical phase of growth.”

Jeb Keiper has 20 years of experience in the pharmaceutical and biotech industries with extensive expertise in financing and business development transactions. Mr. Keiper currently serves as chief financial officer and chief business officer at Nimbus Therapeutics, LLC, where he has overseen over $700m of capital inflows via a variety of financing and partnering transactions since joining in 2014. Prior to joining Nimbus, Mr. Keiper was vice president of business development at GSK Oncology and spent a decade at GSK in various business development leadership roles. Mr. Keiper led the oncology portion of the GSK-Novartis 3-business swap for $16b announced in April 2014. Earlier in his career, Mr. Keiper was a consultant at McKinsey and Company and worked in business development at TransForm Pharmaceuticals. Mr. Keiper began his career at Pfizer R&D as a bench chemist. He received four degrees from MIT: one in Chemistry, two in Chemical Engineering, and an MBA from MIT Sloan.

“Cardurion has built an exceptional company focused on addressing multiple pathways in the cardiomyocyte,” said Mr. Keiper. “I look forward to working with the leadership team and fellow board members as Cardurion continues to build a novel portfolio of clinical and preclinical programs for patients with cardiovascular disease.”

For additional information on Cardurion Pharmaceuticals’ board and leadership team, please visit the company’s website: http://www.cardurion.com.

About Cardurion Pharmaceuticals

Cardurion is a biotechnology company with both clinical and preclinical programs focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Led by two physician-scientists with extensive experience in cardiovascular science, medicine and drug development, Cardurion’s unique programs and strongly collaborative environment enable the company to deliver promising treatments that target major unmet needs. Cardurion has facilities in Cambridge, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

Cardurion Pharmaceuticals’ Forward Looking Statements

This press release contains forward-looking statements, all of which are qualified in their entirety by this cautionary statement. Any statements contained herein that do not describe historical facts, are forward-looking statements that are based on management’s expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcomes, timing and performance to differ materially from those expressed or implied by such statements. These factors, risks and uncertainties include, but are not limited to: the costs and uncertainties associated with our research efforts and other discovery activities; the inherent uncertainties associated with the conduct, timing and results of preclinical and clinical studies of our product candidates; and the adequacy of our capital resources and availability of additional funding. Except as otherwise noted, these forward-looking statements speak only as of the date of this press release, and we undertake no obligation to update or revise any of such statements to reflect events or circumstances occurring after this press release. We caution readers not to place undue reliance on the forward-looking statements contained in this press release.

The safety and efficacy of the agent discussed herein are under investigation and have not been established. There is no guarantee that the agent will receive regulatory approval and become commercially available for the uses being investigated. Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice.

Read More

Cardurion Pharmaceuticals Appoints Rebecca Frey as Chief Operating Officer

CAMBRIDGE, MASS. – [July 24, 2018] – Cardurion Pharmaceuticals, a biotechnology company focused on the development of novel, next-generation therapeutics for the treatment of cardiovascular diseases, today announced that it has expanded its leadership team with the addition of chief operating officer, Rebecca V. Frey, Pharm.D.

“The expansion of our leadership team will not only allow us to streamline and optimize our operations, but further execute on our strategic vision to deliver breakthrough treatments to target major unmet needs in cardiovascular medicine,” said Daniel Bloomfield, M.D., chief executive officer at Cardurion Pharmaceuticals. “Cardiovascular disease is the leading cause of death in both men and women and accounts for one-third of deaths worldwide.1,2 Rebecca’s strategic know-how and operational ingenuity will be critical for Cardurion as we pursue our goal to transform the treatment of cardiovascular disease.”

Rebecca is a highly regarded leader who brings almost 20 years of strategic and operational biotech experience to Cardurion Pharmaceuticals. As chief operating officer, Rebecca will formulate strategies and lead all aspects of operations to maximize value creation. Prior to joining Cardurion Pharmaceuticals, Rebecca served as executive vice president of operations at Prevail Therapeutics, where she led clinical operations and early development planning. Prior to that, Rebecca spent eleven years at Alexion Pharmaceuticals. During her tenure, Rebecca held a wide range of leadership roles in development, project management and manufacturing, including vice president of operations and chief of staff to the CEO. Before Alexion, Rebecca spent six years in clinical operations and medical affairs at Novartis Pharmaceuticals. Rebecca earned her Doctor of Pharmacy from Northeastern University and completed her post-doctoral clinical research fellowship at Northeastern University and Tufts Medical Center. She is a 2017 graduate of the Women in Bio Boardroom Ready program.

“There exists a critical medical need for innovation to overcome the burden of cardiovascular diseases, and I’m pleased to join a world-class team of cardiologists with a deep understanding and desire to advance treatments for patients who are living with heart failure,” said Rebecca Frey, chief operating officer at Cardurion Pharmaceuticals. “I am excited to bring my capability and passion for disciplined execution to Cardurion’s management team, and I look forward to delivering on the company’s strategic priorities.”

For additional information on Cardurion Pharmaceuticals’ leadership team, please visit the company’s website: http://www.cardurion.com.

About Cardurion Pharmaceuticals
Cardurion is a biotechnology company with both clinical and preclinical programs focused on the development of novel, next-generation therapeutics for the treatment of heart failure and other cardiovascular diseases. Led by two physician-scientists with extensive experience in cardiovascular science, medicine and drug development, Cardurion’s unique programs and strongly collaborative environment enable the company to deliver promising treatments that target major unmet needs. Cardurion has facilities in Cambridge, Massachusetts and Shonan, Japan. For more information, please visit the company’s website at http://www.cardurion.com.

Cardurion Pharmaceuticals’ Forward Looking Statements
This press release contains forward-looking statements, all of which are qualified in their entirety by this cautionary statement. Any statements contained herein that do not describe historical facts, are forward-looking statements that are based on management’s expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcomes, timing and performance to differ materially from those expressed or implied by such statements. These factors, risks and uncertainties include, but are not limited to: the costs and uncertainties associated with our research efforts and other discovery activities; the inherent uncertainties associated with the conduct, timing and results of preclinical and clinical studies of our product candidates; and the adequacy of our capital resources and availability of additional funding. Except as otherwise noted, these forward-looking statements speak only as of the date of this press release, and we undertake no obligation to update or revise any of such statements to reflect events or circumstances occurring after this press release. We caution readers not to place undue reliance on the forward-looking statements contained in this press release.

The safety and efficacy of the agent discussed herein are under investigation and have not been established. There is no guarantee that the agent will receive regulatory approval and become commercially available for the uses being investigated. Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice.

American Heart Association, Causes and Risks for Heart Failure (February 2018)
2 American College of Cardiology, Cardiovascular disease causes one-third of deaths worldwide (May 2017)

Media
Stephanie Hutton
W2O pure
shutton@w2ogroup.com
+1 910.726.1367

Read More
page 1 of 2